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Exceptions to the standard macro formula If you are very lean The standard macro formula isnt the best if you have low body fat and a high lean body mass
For example, the SELECT trial revealed that patients on semaglutide maintained an average weight loss of -10.2% over four years (208 weeks), while the placebo group only saw a modest -1.5% reduction
Conclusion: First line use of SGLT2i and GLP-1RAs is effective in reducing HbA1c, weight, and FPG levels in T2DM patients at low risk for cardiovascular disease
Results vary: about one in three people lose 20% or more, while a small proportion see minimal response
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