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4) Figure 4 described a resumptive overview of Wnt/-catenin signalling pathway targeted interventions in cancer therapy as follows: CPG049090, PKF115-584 and PKF222-815 are natural compounds that have been identified to disrupt the interaction of -catenin/TCF complex, suppressing the proliferation of colon cancer cells in vitro assays
Drug development is increasingly moving towards an integrated assessment of environmental and host factors, including the microbiome (35)
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