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Fibrillar structures were also observed, but they were not associated with copper ions, suggesting that copper promotes the formation of toxic oligomers that disrupt membranes ( Impaired autophagy plays an important role in IAPP toxicity, due to the accumulation of excessive amounts of IAPP oligomers intracellularly

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CagriSema cagrilintide 2.4 mg plus semaglutide 2.4 mg was submitted to the FDA on 18 December 2025 for chronic weight management, with the agency expected to review it during 2026