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Limitations & Considerations Much of the published literature on this copper-peptide complex comes from in-vitro and animal-model work rather than large randomized trials, so effect sizes reported in one system do not automatically transfer to another

When GHK-Cu application stops, copper supplementation ceases potentially reducing these enzymatic activities if dietary copper intake and natural skin copper levels prove insufficient for maintaining treatment-level effects

Active IBD or ulcerative colitis (inflammation-driven): KPV is the choice

This matters for hair because follicles sit anchored in that collagenrich dermal matrix when the surrounding collagen network breaks down, the support around follicles weakens, and the scalp tissue becomes more disorganized, changes that are linked to follicle decline and thinning over time