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A recent PET-CT study revealed that metformin enhances glucose uptake in the basolateral area of the intestines, leading to the production of lactate (reducing pH and bicarbonate in portal vein) and acetate that travel to the liver via the portal vein and lower hepatic glucose production (Tobar et al., 2023)
But the top line results remain exciting.
Symptoms associated with gastroparesis include stomach pain, nausea, indigestion, loss of appetite, and vomiting
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