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Tracking these metrics every 2-4 weeks provides more meaningful progress assessment than daily scale weight, which fluctuates with hydration, bowel contents, and other transient factors
In that trial, 4,286 (24.3%) of patients had heart failure with 1,347 of those patients having heart failure with reduced ejection fraction dwarfing the small numbers studied in the initial trials mentioned previously
Adjustments in diet and hydration can also support kidney health, potentially reducing any risks associated with the medication
Most evidence comes from general clinical trial populations rather than studies focused on IBS patients
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