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Our analysis reveals that while Semaglutide effectively reduces body weight in elderly T2DM patients, it paradoxically accelerates this physiological muscle decline, particularly at higher doses and in individuals with pre-existing low muscle mass and function

Compared with a single treatment course (no retreatment), increasing retreatments consistently reduced the ICERs in both the non-T2D and T2D cohorts, indicating that retreatment enhances long-term value

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