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2h, leading to a loss of GLP-1R constitutive activity or capacity to respond to locally produced GLP-1 31

Kapurniotu of the Technical University of Munich, Germany 506 designed a series of peptide-based small molecule inhibitors based on the protein sequences of islet amyloid polypeptide (IAPP), a type of small molecule inhibitor that can inhibit the root causes of amyloid proteins (amyloid- beta peptide and IAPP) aggregation, thus reducing the cytotoxicity of amyloid fibrils, and providing a new idea for the treatment of Alzheimers disease in the clinic

If heart muscle is affected, this could lead to weakness in how the heart pumps, though this is rare

Abbreviations EGCG: Epigallocatechin-3-gallate PARP-1: Poly ADP ribose polymerase-1 LH: Luteinizing hormone FSH: Follicle stimulating hormone pERK: Phosphorylated extracellular signal-regulated kinase SCs: Somatic cells -HSD: Beta-hydroxy steroid dehydrogenase Cyp11A: Cytochrome P450c 11A ROS: Reactive oxygen species ACP: Alkaline phosphatase References WHO manual for the standardized investigation and diagnosis of the infertile couple (1994)