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2.2.3 Beyond the eye In renal tubular cells (Wang et al., 2021) and brain tissue in animal stroke model (He et al., 2020), exenatide and liraglutide activate NAD + -dependent deacetylase SIRT1, reducing mitochondrial dysfunction and oxidative stress by decreasing ROS production, thereby preventing apoptosis induced by lipotoxicity

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Analyzed from the time of treatment initiation, semaglutide was associated with lower 2-year event risk than metformin for all-cause mortality (1.7% versus 3.4%