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Effects of linagliptin treatment on basal insulin and glucagon secretion of human islets varied between diabetic and non-diabetic donors Previous studies have shown beneficial effects of linagliptin on cell survival and function in islets isolated from normal human donors 28
Human Exper Toxicol
In a model of high-fat diet/streptozotocin-induced diabetic rats, Saxagliptin (1 mg/kg for 12 weeks) notably improves pancreatic insulin secretion and increased the -cell to -cell ratio
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