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Taken together, the evidence suggests that class-wide disease modification in Parkinsons, at the compounds and doses tested so far, is unlikely, even if a responder subgroup may yet exist

Clinical experience with approved drugs in this class shows that weight regain typically occurs after discontinuation, which supports long-term use rather than time-limited cycles

The signal strengthened in 2026, when a randomized, placebo-controlled trial published in The Lancet reported that adding once-weekly semaglutide to cognitive behavioral therapy produced robust reductions in heavy drinking among participants with alcohol use disorder and obesity [11]

Satiety: Including protein in meals and snacks enhances satiety and helps prevent overeating by slowing digestion and prolonging the release of hunger-suppressing hormones like GLP-1