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This rigorous analysis examined 17 studies on temperature effects on insulin, finding that unopened vials maintained potency for up to six months at temperatures up to 25C (77F) and up to two months at 37C (98.6F)
doi: 10.1177/13524585231215960
Sub-99% purity introduces synthesis impurities that can bind off-target, alter pharmacokinetics, or produce confounding biological effects
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