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Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 (Peng et al., 2019

1b), those of oxidative stress markers such as protein carbonyl, reactive oxygen species, and lipid peroxidation were elevated in the livers of HFD-fed mice compared to those of controls (Fig

It should be noted that the staining intensity was also higher in the PDL9 group

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