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Review The seminal 1997 review by Kaiser, Sabbagh, Chen, and Wierman in Endocrine Reviews synthesised the evidence base for GnRH regulation of gonadotropin gene expression confirming that LH and FSH mRNA levels in pituitary gonadotrophs are differentially regulated by GnRH pulse frequency and amplitude, with physiological pulsatile gonadorelin being the appropriate experimental tool for studying this differential transcriptional regulation in vitro

This practice enables comparative studies, enhances reproducibility, and speeds peer review

Neurotoxic reactive astrocytes are induced by activated microglia

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