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Clinical trials are designed around percent body weight reduction, achievement of predefined thresholds such as 10 or 15 percent loss, and improvements in obesity-related comorbidities

But in Type 1 diabetes: They do not replace insulin They may promote ketogenesis Insulin dose reductions can trigger euglycemic DKA Appetite suppression and GI effects may worsen metabolic instability Type 1 diabetes management requires maintaining enough insulin not only for glucose control, but also to suppress ketone production

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Regular use can lead to improved skin texture, reduced appearance of fine lines, and enhanced skin elasticity