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GSSSG (FW: 644.70), which has also exhibited a potent preventive effect on HGF nitration (Figure 1b), did not show an enhancement of c-met binding with HGF, as described earlier (Figure 1e bars 47 ), directly encouraging the notion that there is a nitration-independent mechanism centered on the unique characteristics of LASSS on HGF

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Precursor selection decision = most intense, top 20, isolation window = 1.6, scan range = auto normal, first mass = 110, collision energy 30%, CID, Detector type = ion trap, OT resolution = 30 K, IT scan rate = rapid, max injection time = 75 ms, AGC target = 10,000, Q = 0.25, inject ions for all available parallelizable time

The subcutaneous tissue surrounding the knee provides adequate proximity for peptide diffusion to ligaments, tendons, and the joint capsule