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Inclusion criteria: Studies on GLP-1 and inflammation Arthritis-related experimental models Publications from 20052025 Exclusion criteria: Non-peer-reviewed articles Studies lacking quantitative data Researchers extracted data about cytokine levels, receptor expression, and cartilage outcomes
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Then I did a bunch of in vitro receptor activation assays to demonstrate that the molecule I designed interacted with the GLP-1 and GIP receptors, which is actually not something you can really measure in the body, where you have to look at things like impact on weight or glycemic control. Animal studies then followed, which were really all about safety and toxicity to demonstrate that even at extremely high levels, it wouldnt be dangerous, he added
(2019c)
