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It has been reported that whey protein treatment added myocardial GSH/GPX content and decreased ROS in a mouse model of chronic iron overload cardiomyopathy [105]

Serious hypersensitivity reactions have also been reported during postmarketing use with other GLP-1 receptor agonists

For such drugs, target engagement studies can confirm that the drug binds to the receptor, but also, can allow for calculations of the relative effect the drug is having on the respective receptor system