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1 Tirzepatide 15 mg: -11.2 kg average weight loss Injectable semaglutide 1 mg: -5.7 kg average weight loss HbA1c: -2.30% with tirzepatide 15 mg vs -1.86% with semaglutide 1 mg Rybelsus 14 mg (the highest available oral dose) produces roughly equivalent blood levels to injectable semaglutide 0.5-1.0 mg per week, which is at or below the injectable dose tested in SURPASS-2
Most individuals start seeing noticeable weight loss within a few months, but the response to the medication can vary
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They are generally mild to moderate, most intense when starting or increasing the dose, and usually subside with time
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