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A later study confirmed these effects extend to both dopamine and serotonin turnover across multiple brain regions (Sikiri et al., Curr Pharm Des, 2010)
B12 primarily supports nerve health, brain function, and energy production
In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures
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