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doi: 10.1016/j.advnut.2023.04.004 58 WortmannSBMayrJA
Animal-model evidence is strong: rat ulcerative colitis, ileoileal anastomosis (Vuksic 2007), gastric-mucosal protection studies (Sikiric multi-paper)
Long-Term Effects (4 Weeks and Beyond) For many individuals, the most reliable hunger suppression occurs after about 4 weeks of use, with hunger levels consistently lower over time
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