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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon
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Thompson P, Ferrajoli A, Keating M, Banerjee P, Andreeff M , Rezvani K, Wierdaiw W
Journal of Anti-Aging Medicine, 4(2), 133-144
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