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For both men and women, hormone changes may contribute to stubborn weight gain, difficulty losing weight, fatigue, and changes in overall wellness

This study also identified the depletion of the purine metabolite, hypoxanthine, in chronic fatigue patients (according to Canadian Consensus criteria) which may impair ATP production and contribute to the biochemical changes associated with PEM

GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda), are increasingly prescribed for type 2 diabetes and weight management

While the peptide does not increase IGF-1, caution is warranted given the theoretical relationship between growth factors and cancer progression