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Moreover, patients without preexisting conditions, such as moderate-to-severe CKD and chronic ischemic heart disease, showed more pronounced risk reductions (HR = 0.69 and HR = 0.66, respectively) than their counterparts (HR = 0.75 and HR = 0.80, respectively)

Patients with significant comorbidities, prior medication side effects, or requiring rapid dose escalation should discuss with a provider whether a personalized, potentially higher-dose approach justifies the cost difference

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