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Rotate sites with each injection to prevent lipohypertrophy, which is the buildup of fibrous tissue at repeatedly injected locations
The nitrogen atoms on the histidine imidazole ring and glycine amine backbone coordinate with Cu with extremely high binding affinity, forming a stable bioavailable chelate complex
There is still a need to investigate further potential treatment in vivo since their clinical translation is still limited
A separate analysis in Nature Medicine found that retatrutide produced significant reductions in liver fat content in participants with metabolic dysfunction-associated steatotic liver disease (MASLD), suggesting benefits beyond simple weight reduction
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