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That triple mechanism delivered up to 24.2% mean body weight loss in phase 2 trials and up to 28.7% in the recently completed TRIUMPH-4 phase 3 trial

Despite these setbacks, encouraging animal data warrant future efforts for the development of new drugs capable to activate synergistically both GPR40 and GPR120 and mediate, through GLP-1 and other intestinal, pancreatic and cerebral peptides, better treatments for multifactorial chronic metabolic diseases

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[8] Hydration status: Gastrointestinal side effects such as vomiting and diarrhoea increase the risk of dehydration, which is a well-recognised contributor to fatigue