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In addition, at high concentrations calcidiol can displace calcitriol from vitamin D binding protein resulting in increased free calcitriol that can then activate the VDR

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These come with certain risks for anyone on medication or with a condition that affects their blood pressure, so its especially important that you discuss adding any such supplements with your doctor

S., Dostert, C., Nonnenmacher, Y., Cox, M., Binsfeld, C., Hao, Z., Brstle, A., Itsumi, M., Jger, C., Chen, Y., Pinkenburg, O., Camara, B., Ollert, M., Bindslev-Jensen, C., Vasiliou, V., Gorrini, C., Lang, P