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Limitations Few studies evaluated newer medications (e.g., GLP-1 receptor agonists) with follow-up beyond 12 months
"While GLP-1 medications provide powerful support for weight management, the degree of weight loss depends heavily on adherence to a modest caloric deficit below total daily energy expenditure and on engaging in regular physical activity to increase caloric utilization," he explains
Studies show that most patients regain a significant portion of lost weight within months of stopping treatment as appetite returns to pre-treatment levels and metabolic signaling reverts
Locally, there is no DPP-4 expression in taste tissue, which could suggest that in this location, GLP-1 may achieve a longer half-life (167)
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