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2.3 Treatment Algorithm Starting from the defined baseline cohort characteristics, the treatment algorithms modelled an initial year of HbA1c reduction equal to the reported efficacy of one of the medications as reported in the key trials (i.e., semaglutide/empagliflozin/canagliflozin/sitagliptin), as well as changes in other key biomarkers including systolic blood pressure, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, body mass index (BMI), estimated glomerular filtration rate, and non-severe and severe hypoglycaemic events for patients
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