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Klotho mimetics can theoretically suppress phosphate reabsorption in the kidneys, and if KLOW replicates this effect at high doses, the result is phosphate depletion that manifests as muscle weakness, bone demineralization, and in severe cases, rhabdomyolysis

"This research is very important because alcohol and drug addiction are major causes of illness and death, yet there are still only a few effective treatment options," said lead researcher Lorenzo Leggio, MD, Ph.D., of the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism

Curr Opin Investig Drugs 11:440446 Yazbeck R, Sulda ML, Howarth GS, Bleich A, Raber K, von Hrsten S, Holst JJ, Abbott CA (2010b) Dipeptidyl peptidase expression during experimental colitis in mice