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To better understand the reliability of the reviewed studies, we conducted a methodological quality assessment based on key design features, including randomization, blinding, use of control groups, and sample size
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Post-ischemic glutamate surges activate NMDA receptors clustered in lipid rafts, causing lethal calcium influx and neuronal death, and interventions targeting raft cholesterol (e.g., statins) reduce NMDA receptor hyperactivation (Besshoh et al., 2005
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