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Patients with pernicious anemia, intrinsic factor deficiency, or renal impairment require provider oversight
Am J Clin Nutr 1998, 68: 380-388
Retatrutide activates three receptors simultaneously (GLP-1, GIP, glucagon) where semaglutide activates only one (GLP-1)
Participants with type 2 diabetes lost weight somewhat more slowly than those without diabetes (19.7% versus 24.2% at 48 weeks in the Phase 2 trial), though the difference narrowed at higher doses
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