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This upregulation reduces the sensitivity of nasopharyngeal carcinoma (NPC) cells to ferroptosis, thereby fostering chemoresistance and tumor progression ( Figure 6 Overall, as a carcinogenic virus, EBV shares similar mechanisms with HBV, both of which facilitate tumor progression and induce chemotherapy resistance by suppressing ferroptosis sensitivity in tumor cells

The interplay between androgen/AR signaling and other sex steroid- or growth factor-dependent pathways will be also presented, together with its putative contribution to age-related frailty