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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+
Improves survival under oxidative stress by increasing nitric oxide (NO) expression, thereby protecting the endothelial lining of the blood vessels from oxidative damage
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