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Synthetic GLP-1 agonists activate GLP-1 receptors in the pancreas , increasing cyclic adenosine monophosphate (cAMP)
Is One More Effective for Type 2 Diabetes Management
In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents
(Sources: 1, 3) 3
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