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In addition to preventing toxin accumulation, glutathione assists in their removal
Our group recently described that a genetic disruption of the xCT subunit using CRISPR-Cas9 inhibits protein synthesis and proliferation in vitro ( 14 C-cystine transport assay in xCT knockout (xCT-KO) cells revealed this transporter as unique and indispensible for cystine uptake, as a complete abolishment of cystine transport has been observed
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