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However, its vital to approach their usage cautiously, under medical supervision, due to potential side effects and regulatory concerns

Preclinical studies have also pointed out that AMPK activates SIRT1 by up-regulating the NAD+ levels, which in turn promotes the deacetylation of SIRT1 and activates PGC-1, thereby forming the AMPK-SIRT1-PGC-1 signaling axis

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