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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort
The pattern is clear: every step up the dose ladder brings a fresh wave of GI symptoms
motion sickness appears to involve muscarinic transmission , which accounts for scopolamine's known ability to prevent this disturbance (Pappano, 2015)
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