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The translational pathway would benefit from early thoughts from materials science, clinical, and regulatory experts to co-design delivery formats (e.g., special nanocomposite antimicrobial coatings that rapidly kill persisters on catheters) and to co-plan staged clinical trials with microbiological markers of success (i.e., MBEC reduction and no relapse) and not just surrogates of colonization
It is important to administer the medication on the same day each week (for weekly formulations) or at the same time each day (for daily formulations) to maintain stable blood levels and optimise efficacy
2011;34(Suppl 2):S279-S284
Diagnosis codes to assist in identifying retinal disorders
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