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The maximum dose tested in Phase 2 was 12mg once weekly, where 24.2% body weight loss was recorded at 48 weeks (Jastreboff et al., NEJM 2023)
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Maria Masters Author Maria Masters is a contributing editor and writer for Everyday Health and What to Expect, and she has held positions at Men's Health and Family Circle
Quick Answer: Semaglutide has been studied for over 14 years, with clinical trials beginning in the early 2010s and approximately 7 years of real-world post-marketing experience since FDA approval in December 2017
Semaglutide is also very effective, leading to an average weight loss of around 14.9%, making tirzepatide the more potent option based on current data
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