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Depending on the substance and activity, researchers and organizations may need to consider: Institutional approval and oversight Import and customs requirements Controlled-substance requirements Laboratory safety and chemical-handling procedures Human or animal research ethics approval Health-product and clinical-trial requirements Provincial, municipal, workplace, or professional rules Recordkeeping, storage, and disposal requirements Organizations should obtain qualified legal or regulatory advice before acquiring or working with a material when its status is uncertain

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Through its interaction with CAan enzyme essential for maintaining the carbon dioxidebicarbonate balance and physiological pHPolmacoxib may modulate COX-2 inhibition in cardiovascular tissues where both pathways coexist

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia