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Studies in animal models have shown an anorexigenic action of GIP receptor agonism [36] and a recent phase 1 clinical trial with a long-acting GIP RA found that repeated dosing for 4 weeks induced modest WL (1.9 to 3.1 kg vs
Despite the drugs cardiovascular benefits, both trials found no significant difference in retinopathy outcomes between the GLP-1RAs and placebo groups
Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
After four weeks, potency drops below 50%
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