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In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH)

This interaction increases cell surface ATP levels, which then activates P2X4 purinergic receptors

Research suggests it may upregulate collagen expression and growth factor signaling in cell and animal models, though translation to clinical efficacy in humans remains preliminary and requires additional rigorous studies

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