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They also had increased oxidative stress, demonstrated by higher levels of glutathione peroxidase (GPx), lipid peroxidation products (MDA), protein oxidation, and superoxide anions in both cortex and hippocampus in this group

In this study, embryonic stem cells were transfected with a dominant-negative N-cadherin mutant (NCAD delta) under the control of the Villin promoter, which is active primarily in intestinal epithelial cells, and then were introduced into C57BL/6 mouse blastocysts

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