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According to Sharath Chandra Guntuku, Research Associate Professor in Computer and Information Science (CIS) at Penn Engineering and the study's senior author, Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal. The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them, Guntuku added
Together, these results show that orforglipron produces a behavioural profile distinct from both nausea-like and satiety states, suggesting that its anorectic effects are separable from aversion
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