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Future Research Directions and Unanswered Questions Despite 50+ years since Pickarts initial isolation work, significant mechanistic and clinical questions remain: Receptor identity: GHK-Cus gene regulatory effects are well-documented, but the specific cellular receptors mediating them remain incompletely characterized

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(2021) Engineered enzymes enable selective Nalkylation of pyrazoles with simple haloalkanes, Angewandte Chemie , 60 , 5554-5560, Peng, Y., Sartini, D., Pozzi, V., Wilk, D., Emanuelli, M., and Yee, V