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It is possible that such minor gene effects may be additive and particular combinations of polymorphisms from different genes may confer neuroprotection
Gu 2015)
The clinical relevance of these results seems also highlighted by the evidence that for some outcomes the clinical benefit is consistent irrespective of the presence of type 2 diabetes [13], advanced age [13, 30], and the background cardiorenal disease [12, 15, 31]
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