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Ideal candidates typically include patients with: Type 2 diabetes and NAFLD/MASLD : This represents the most straightforward indication, as GLP-1 agonists are FDA-approved for diabetes management
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
In a study by Zrelli et al., HTY promoted wound healingrelated responses in vascular endothelial cells, and this effect was associated with increased activity of the Nrf2 pathway
therefore, SSRIs in general and fluoxetine in particular should be used with caution (Sjaarda et al., 2020)
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