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Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation
High levels of oxidative stress may be a precursor to multiple diseases including but not limited to: diabetes, cancer, and rheumatoid arthritis
In adults, mature erythrocytes develop as a result of erythropoiesis from bone marrow-located hematopoietic stem cells through a gradual and consequent process that includes stepwise formation of myeloid progenitors, megakaryocytic-erythroid progenitors, burst-forming unit-erythroids (BFU-e) and colony-forming unit-erythroids (CFU-e), proerythroblasts, basophilic, polychromatic, and orthochromatic erythroblasts, reticulocytes, and eventually mature erythrocytes [30, 31]
This is a big issue for GLP-1 weight-loss drugs, which must be taken for life and as often as daily
