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This was shown in a study of 86,000 adults with obesity
Journal of Diabetes and Metabolic Disorders
In addition to oral l-carnitine, metformin was administered either intraperitoneally (ip, solubilized in 0.9% NaCl) at a concentration of 100 mg/kg of rat weight twice a day for 4 weeks in the l-carnitine + Metformin group [28]
Instead, it operates through nutritional biochemistry: providing substrate for methylation reactions, phospholipid assembly, and mitochondrial energy production
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